Empagliflozin Improves Cardiac Functional Recovery after Prolonged Cold Storage of Donor Hearts in an Isolated Working Rat Heart Model

Supplementation of cardiac preservation solution with 10µM Empa yields significantly improved functional recovery after prolonged cold storage, with similar cardioprotective efficacy to the NHEI zoniporide. Given the approved clinical use of Empa, this study highlights its potential as a suitable alternative for NHEI in donor heart preservation.