The RESOLUTE consortium: unlocking SLC transporters for drug discovery Giulio Superti-Furga , Daniel Lackner , Tabea Wiedmer , Alvaro Ingles-Prieto , Barbara Barbosa , Enrico Girardi , Ulrich Goldmann , Bettina Gürtl , Kristaps Klavins , Christoph Klimek , Sabrina Lindinger , Eva Liñeiro-Retes , André C. Müller , Svenja Onstein , Gregor Redinger , Daniela Reil , Vitaly Sedlyarov , Gernot Wolf , Matthew Crawford , Robert Everley , David Hepworth , Shenping Liu , Stephen Noell , Mary Piotrowski , Robert Stanton , Hui Zhang , Salvatore Corallino , Andrea Faedo , Maria Insidioso , Giovanna Maresca , Loredana Redaelli , Francesca Sassone , Lia Scarabottolo , Michela Stucchi , Paola Tarroni , Sara Tremolada , Helena Batoulis , Andreas Becker , Eckhard Bender , Yung-Ning Chang , Alexander Ehrmann , Anke Müller-Fahrnow , Vera Pütter , Diana Zindel , Bradford Hamilton , Martin Lenter , Diana Santacruz , Coralie Viollet , Charles Whitehurst , Kai Johnsson , Philipp Leippe , Birgit Baumgarten , Lena Chang , Yvonne Ibig , Martin Pfeifer , Jürgen Reinhardt , Julian Schönbett , Paul Selzer , Klaus Seuwen , Charles Bettembourg , Bruno Biton , Jörg Czech , Hélène de Foucauld , Michel Didier , Thomas Licher , Vincent Mikol , Antje Pommereau , Frédéric Puech , Veeranagouda Yaligara , Aled Edwards , Brandon J. Bongers , Laura H. Heitman , Ad P. IJzerman , Huub J. Sijben , Gerard J.P. van Westen , Justine Grixti , Douglas B. Kell , Farah Mughal , Neil Swainston , Marina Wright-Muelas , Tina Bohstedt , Nicola Burgess-Brown , Liz Carpenter , Katharina Dürr , Jesper Hansen , Andreea Scacioc , Giulia Banci , Claire Colas , Daniela Digles , Gerhard Ecker , Barbara Füzi , Viktoria Gamsjäger , Melanie Grandits , Riccardo Martini , Florentina Troger , Patrick Altermatt , Cédric Doucerain , Franz Dürrenberger , Vania Manolova , Anna-Lena Steck , Hanna Sundström , Maria Wilhelm , Claire M. Steppan Nature Reviews Drug Discovery（2020）
Abstract
The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class.
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