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An interaction between CaMKII and calpain mediates myocardial ischemia/reperfusion injury

Hongting Lu,Lingheng Kong,Renqian Feng,Jiakun Tang,Jingjun Zhou,Feng Gao, Jun Ren

Journal of Molecular and Cellular Cardiology（2020）

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Abstract
We have previously demonstrated that Ca2+/calmodulin-dependent kinase II (CaMKII), a kinase involved in modulating intracellular Ca2+ homeostasis, activates the Ca2 + −regulated protease m-calpain and promotes myocardial ischemia/reperfusion injury. This study was to investigate the underneath regulatory mechanisms.
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Key words
calpain mediates,myocardial ischemia/reperfusion,camkii
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