An Efficient Synthesis of Natural Tribolure
Chemistry of Natural Compounds(2020)
摘要
n efficient synthesis of natural tribolure has been achieved through an asymmetric methylation as a key step. Natural tribolure is a mixture of four stereoisomers, so racemic 2-methylbutan-1-ol was used as starting material. After a C5+C4 strategy and then a mixed Evan’s template inductive methylation, the key intermediate was obtained. Finally, the natural product tribolure (4:4:1:1 of stereoisomers, respectively) was obtained in 10 linear steps and in 34.2% overall yield.
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关键词
aggregation pheromone,synthesis,Evan′s template,asymmetric alkylation
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