HILIC LC-MS/MS method for the quantification of cefepime, imipenem and meropenem
Journal of Pharmaceutical and Biomedical Analysis(2020)
Abstract
•Accurate and robust HPLC–MS/MS method for cefepime, imipenem and meropenem.•TurboFlow column is used for online sample preparation and HILIC column for separation.•Plasma and CSF can be analyzed simultaneously.•Results from over one year of routine measurements show the value of this method.
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Key words
High pressure liquid chromatography,Mass spectrometry,Online extraction,Protein precipitation,Antibiotics,Therapeutic drug monitoring
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