Donor T and NK cells with a special tissue-resident memory phenotype migrate into the periphery of lung transplant recipients - a potential feature for tolerance development
EUROPEAN JOURNAL OF IMMUNOLOGY(2023)
摘要
Our results demonstrate that donor T and NK cells found in the blood of LuTx recipients are a distinct subset from circulating lymphocytes and TRM cells present in lung tissue, since they express CD69 but lack expression of other classical TRM markers. They display a higher functional capacity despite the onset of immunosuppression. Donor T cells might be clinically relevant for tolerance induction and long-term survival after transplantation due to their unique features.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要