Transcriptome Analysis of Airway Brushes in Lung Transplant Recipients with and without Chronic Lung Allograft Dysfunction

C.J. Iasella,M. Snyder,I. Popescu,J. Wei,A. Hoji,Y. Zhang, W. Xu, V. Iouchmanov,M. Brown, E. Lendermon, B. Johnson,S. Kilaru,M. Morrell,J. Pilewski,J. Greenland, K. Chen,J.F. McDyer

JOURNAL OF HEART AND LUNG TRANSPLANTATION（2020）

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摘要

Transcriptome analyses of bronchial brush samples revealed activation of Type-1 immune responses. Furthermore, this signature appears to strengthen over time as patients progress to CLAD and in later stages of CLAD. Further analyses may provide the rationale for testing select immune targets in CLAD and uncover distinct immune endotypes within CLAD.

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