Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

Mia Ståhle,Johanna M.U. Silvola,Sanna Hellberg,Margreet de Vries,Paul H.A. Quax,Jeffrey Kroon,Petteri Rinne,Alwin de Jong,Heidi Liljenbäck,Nina Savisto, Anna Wickman,Erik S.G. Stroes,Seppo Ylä-Herttuala,Pekka Saukko, Tommy Abrahamsson,Knut Pettersson,Juhani Knuuti,Anne Roivainen,Antti Saraste

JACC: Basic to Translational Science（2020）

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摘要

•Phosphorylcholine is a pro-inflammatory epitope in atherogenic oxidized phospholipids.•This study investigated effects of a novel monoclonal IgG1 antibody against PC on vascular function and atherosclerotic inflammation.•Treatment with phosphorylcholine antibody preserved coronary flow reserve and decreased uptake of 18F-FDG in atherosclerotic lesions in hypercholesterolemic mice.•Noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis.

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关键词

atherosclerosis,coronary flow reserve,inflammation,18F-fluorodeoxyglucose positron emission tomography,phosphorylcholine

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