Extension of Coronavirus Disease 2019 on Chest CT and Implications for Chest Radiographic Interpretation

Purpose: To study the extent of pulmonary involvement in coronavirus 19 (COVID-19) with quantitative CT and to assess the impact of disease burden on opacity visibility on chest radiographs. Materials and Methods: This retrospective study included 20 pairs of CT scans and same-day chest radiographs from 17 patients with COVID-19, along with 20 chest radiographs of controls. All pulmonary opacities were semiautomatically segmented on CT images, producing an anteroposterior projection image to match the corresponding frontal chest radiograph. The quantitative CT lung opacification mass (QCT mass) was defined as (opacity attenuation value 1 1000 HU)/1000 3 1.065 (g/mL) 3 combined volume (cm3) of the individual opacities. Eight thoracic radiologists reviewed the 40 radiographs, and a receiver operating characteristic curve analysis was performed for the detection of lung opacities. Logistic regression analysis was performed to identify factors affecting opacity visibility on chest radiographs. Results: The mean QCT mass per patient was 72.4 g 6 120.8 (range, 0.7-420.7 g), and opacities occupied 3.2% 6 5.8 (range, 0.1%-19.8%) and 13.9% 6 18.0 (range, 0.5%-57.8%) of the lung area on the CT images and projected images, respectively. The radiographs had a median sensitivity of 25% and specificity of 90% among radiologists. Nineteen of 186 opacities were visible on chest radiographs, and a median area of 55.8% of the projected images was identifiable on radiographs. Logistic regression analysis showed that QCT mass (P,.001) and combined opacity volume (P,.001) significantly affected opacity visibility on radiographs. Conclusion: QCT mass varied among patients with COVID-19. Chest radiographs had high specificity for detecting lung opacities in COVID-19 but a low sensitivity. QCT mass and combined opacity volume were significant determinants of opacity visibility on radiographs. Earlier incorrect versions appeared online. This article was corrected on April 6, 2020 and December 14, 2020.