A Perspective On Dna Damage-Induced Potentiation Of The Pentose Phosphate Shunt And Reductive Stress In Chemoresistance
MOLECULAR & CELLULAR ONCOLOGY(2020)
摘要
Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.
更多查看译文
关键词
DNA damage, DNA repair, metabolism, pentose phosphate pathway, redox
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要