Human organoids to model the developing human neocortex in health and disease.

•Several different protocols to generate human cerebral organoids are compared.•Organoid protocols recapitulate key stages of human cortical development.•Time in culture to reach milestones varies considerably between organoid protocols.•Modeling all cell types including glia and the vasculature is a major challenge.•Organoids are a promising approach to model diseases and develop new treatments.