Tissue Specific Reductions in Sirtuin-6 Expression Affect Calcium Burden and Pro-osteogenic Signaling in the Aortic Valve
Arteriosclerosis, Thrombosis, and Vascular Biology(2019)
Abstract
Sirtuin-6 (SIRT6) is a protein deacetylase that functions in several pathways related to aging, as complete loss of SIRT6 in mice elicits multiple age-associated phenotypes and premature death. Whi...
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Key words
aortic valve,calcium,tissue specific reductions,pro-osteogenic
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