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Tissue Specific Reductions in Sirtuin-6 Expression Affect Calcium Burden and Pro-osteogenic Signaling in the Aortic Valve

Sahithi Puvvala,Leslie A. Smith,Bin Zhang,Grace C. Verzosa,Runqing Huang,Carolyn M. Roos,Jordan D. Miller

Arteriosclerosis, Thrombosis, and Vascular Biology（2019）

Cited 23|Views19
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Abstract
Sirtuin-6 (SIRT6) is a protein deacetylase that functions in several pathways related to aging, as complete loss of SIRT6 in mice elicits multiple age-associated phenotypes and premature death. Whi...
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Key words
aortic valve,calcium,tissue specific reductions,pro-osteogenic
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