Circulating Tumor Hpv Dna Characteristics In High Risk Oropharyngeal Squamous Cell Carcinoma

Human papillomavirus (HPV) circulating tumor (ct) DNA is a putative prognostic biomarker in HPV-related oropharyngeal squamous cell carcinoma (OPSCC). HPV ctDNA levels have been shown to correlate with total disease burden in recurrent/metastatic OPSCC. During definitive chemoradiation, a rapid clearance profile of HPV ctDNA is associated with decreased risk of locoregional recurrence; and an increase in HPV ctDNA after treatment is correlated with disease recurrence. We assessed HPV ctDNA characteristics in high risk stage III p16+ OPSCC treated on a prospective randomized trial.