De-Escalated Adjuvant Therapy after Transoral Robotic Surgery for HPV related Oropharyngeal Carcinoma: The SiRS Trial

B. Miles, M. Posner, M.S. Teng,M. Yao,R. Chai,K. Misiukiewicz,V. Gupta,R.L. Bakst,S. Sharma, D. Zhang,F. Ye,W.H. Westra,S. Kim-Schulze,S. Sobotka,A. Sikora,P. Som,E. Genden

International Journal of Radiation Oncology*Biology*Physics（2020）

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摘要

Improved survival rates after treatment ofHPV related oropharyngeal SCChave resulted in “de-escalation” strategies to preserve survival while limiting toxicity. We hypothesized that transoral robotic surgery (TORS) for early T-stage disease withpathologic stratification andreduced dose adjuvant therapy would result in equivalent PFS and OS while reducing toxicity and preserving long term quality of life.

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关键词

oropharyngeal carcinoma,transoral robotic surgery,adjuvant therapy,hpv,sirs trial,de-escalated

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