Resolution of racemic1-(4-methoxyphenyl) ethanol using immobilized lipase with high substrate tolerance

Bin Wang,Binglong Zhu,Jie Gong,Jushi Weng,Feifei Xia,Weiqiao Liu

Biochemical Engineering Journal（2020）

引用 7|浏览5

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摘要

•The resolution of (R,S)-MOPE was firstly conducted with high concentration using PM1000-TiO2-lipase.•High conversion 49.1 % and excellent ee 99.1 % were attained.•PM1000-TiO2-lipase maintained 86.0 % relative activity after ten batch reactions.•A ping-pong Bi-Bi mechanism without inhibition model was fitted.

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关键词

Immobilized enzyme,Lipase YCJ01,Resolution,(R,S)-1-(4-methoxyphenyl) ethanol

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