A Facile and Catalyst-free Synthesis of Hexahydroacridine-1,8(2H,5H )-dione and Octahydroacridin-10(1H )-yl)thiourea Derivatives: Inter- and Intramolecular Aza-Michael addition
HETEROCYCLIC COMMUNICATIONS(2020)
Abstract
An easy and convenient technique for the one-pot synthesis of novel compounds of hexahydroacridine-1,8(2H,5H)-dione and octahydroacridin-10(1H)-yl) thiourea derivatives has been developed by the reaction of the octahydro-1H-xanthenes with hydroxylamine hydrochloride and thiosemicarbazide in ethylene glycol, which is a green solvent, under mild reaction conditions. IR, H-1 NMR, C-13 NMR spectrometry, and X-ray diffraction analysis were used to identify the structures of these compounds.
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Key words
Cyclohexanedione,Octahydro-1H-xanthene,Acridine,X-ray,1D-Polymeric H-bond
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