The Effect of Hydroalcoholic Extract of Rumex scutatus and Cerasus vulgaris on Blood Glucose, Lipids and Histopathology of Streptozotocin Induced Diabetic Rats

Background: Reducing glucose levels in diabetic patients has a lot of clinical significance. Due to the side effects of drugs, finding plants with similar properties will be very helpful. Objective: The purpose of the present study was to determine the effect of hydroalcoholic extract of Rumex scutatus (Rs) and Cerasus vulgaris (Cv) on the serum levels of glucose, lipid profile and histopathological changing in Streptozotocin (STZ)-induced diabetic rats. Method: In this experimental study 24 male white Wistar rats were designated into 4 groups (6 rats per group) randomly. Healthy controls, Diabetic control, Diabetic rats treated with Rs (200 mg/kg), Diabetic rats treated with Cv (250 mg/kg). All of the rats were treated with gavage injection for 3 weeks. At the end of the experiment, serum levels of glucose and lipids were assessed. Sampling from the pancreas, liver and kidney tissues were performed in all animals of the groups. Data were analyzed by one way variance analysis (ANOVA) and Tukey’s and Bonferronichr('39')s test using SPSS software. Results: Rs (200 mg/kg) significantly decreased the level of serum glucose, cholesterol, TG, LDL, and VLDL, but on HDL profile was not significant the effect of Cv (250 mg/kg) on glucose and lipid profiles in diabetic rats were not significant. The hydroalcoholic extract of Rs reduced the tissue damages resulted from diabetic better than the hydroalcoholic extract of Cv. Conclusion: According to the results, consumption of Rumex scutatus and Cerasus vulgaris can affect the complications of diabetes, dyslipidemia; regulate the level of blood glucose and lipids in these patients.