Oral Pigmentations Of Laugier-Hunziker Syndrome: An Important Differential Diagnosis For Peutz-Jeghers Syndrome

Oral pigmentation is seen fairly commonly in dermatologic practice. Oral pigmentation associated with Laugier-Hunziker syndrome (LHS) is an uncommon condition that shares some dermatologic features with Peutz-Jeghers syndrome (PJS). It is benign and asymptomatic, with no known cause, and is often associated with pigmentation of the nails and other mucosal surfaces. LHS and PJS show very similar skin manifestations but there age of onset, genetics, predilection site and associated systemic disease are different. However, evaluation of intestinal polyps should be performed for accurate differential diagnosis. We present seven patients whose conditions highlight the clinical syndrome known as LHS, and use the opportunity to review its clinical and pathologic features, and the relevant literature.