Key read across framework components and biology based improvements

Nicholas Ball,Judith Madden,Alicia Paini,Miriam Mathea,Andrew David Palmer,Saskia Sperber,Thomas Hartung,Bennard van Ravenzwaay

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2020）

引用 18|浏览40

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摘要

•Read-across is most frequently used method to reduce animal testing under REACH.•Read across improvements achieved by metabolomics.•Kinetics are a key component of read across.•Big data analysis offers new opportunities for read across.

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关键词

REACH,Read-across,In silico,Metabolomics,PBPK modelling

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