Outside Front Cover: Biotechnology Journal 3/2020
Biotechnology Journal(2020)
摘要
A label-free and enzyme-free uracil DNA glycosylase (UDG) activity assay is described. In the upper left bubble, detection duplex probe serving as substrate for UDG releases a catalyst strand (blue strand) due to the UDG-catalyzed degradation of uracil, which subsequently promotes the toehold-mediated strand displacement (TMSD) reaction in the upper right bubble. As a result, active split G-quadruplexes are produced leading to the colorimetric response in the bottom bubble. This is reported by Youna Kim, Yeonkyung Park, Chang Yeol Lee, Hyun Gyu Park in article 1900420.
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biotechnology journal
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