Outside Front Cover: Biotechnology Journal 3/2020

A label-free and enzyme-free uracil DNA glycosylase (UDG) activity assay is described. In the upper left bubble, detection duplex probe serving as substrate for UDG releases a catalyst strand (blue strand) due to the UDG-catalyzed degradation of uracil, which subsequently promotes the toehold-mediated strand displacement (TMSD) reaction in the upper right bubble. As a result, active split G-quadruplexes are produced leading to the colorimetric response in the bottom bubble. This is reported by Youna Kim, Yeonkyung Park, Chang Yeol Lee, Hyun Gyu Park in article 1900420.