Controlled Stepwise Synthesis And Characterization Of A Ternary Multicomponent Crystal With 2-Methylresorcinol

A typical approach of a multicomponent crystal design starts with a retrosynthetic analysis of the target molecule followed by a one-pot reaction of all components. To develop protocols for multicomponent crystal syntheses, controlled stepwise syntheses of a selected crystalline ternary multicomponent system 1 involving 2-methylresorcinol (MRS), tetramethyl-pyrazine (TMP), and 1,2-bis(4-pyridyl)ethane (BPE) are presented. The obtained binary cocrystals 2 (involving MRS and TMP) and 3 (involving MRS and BPE) as well as the final resulting ternary multicomponent system 1 were characterized by X-ray analysis.