Assessments of plasma acyl-ghrelin levels in Parkinson's disease patients treated with deep brain stimulation.

•STN DBS is an established treatment in advanced PD, however there is limited evidence that may causes changes of ghrelin levels.•The results showed that STN DBS therapy elicited a modification of ghrelin levels. Body weight increased 3 months after surgery. There was no correlation between the ghrelin plasma levels and BMI.•Further research is warranted to explore of the gastrointestinal endogenous peptides in patients following STN DBS and the role of ghrelin in the gut/brain hormonal axis.