Recent developments and strategies for the discovery of TACE inhibitors

Introduction: TNF-alpha plays a central role in certain autoimmune diseases as well as in inflammation. The current strategy for excluding TNF-alpha from circulation is to selectively inhibit TNF-alpha converting enzyme (TACE), an enzyme that cleaves mTNF-alpha to active TNF-alpha. Various TACE inhibitors have been discovered by using different strategies to control inflammatory diseases, cancer, and cardiac hypertrophy. Areas covered: The present article summarizes the design and discovery of novel TACE inhibitors that have been reported in the literature since 2012 onwards. It also includes some reports concerning the new role that TACE plays in cancer and cardiac hypertrophy. Expert opinion: So far, undertaken studies that have looked to design and develop small TACE inhibitors have been discouraging due to the failure of any TACE inhibitors to hit the market. However, some of the latest developments, such as with tartrate-based inhibitors, has given hope to the potentiality of a viable novel selective TACE inhibitor therapeutic in the future. Indeed, some of the novel peptidomimetics and monoclonal antibodies have great potential to pave the way for an effective and safe therapy by selectively inhibiting TACE enzyme.