IL-37 is protective in allergic contact dermatitis through mast cell inhibition
International Immunopharmacology（2020）
Abstract
•IL-37 attenuated inflammation, MC recruitment, IgE and IL-33 release in ACD rats.•IL-37 inhibited IL-33-stimulated MC inflammation and IgE-induced degranulation.•Regulation of Smad3 participated in the anti-ACD effect of IL-37.
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Key words
Interleukin-37,Mast cells,Allergic contact dermatitis,Inflammation,NF-κB,P38MAPK
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