RNA interference-mediated silencing of Kv7.2 in rat dorsal root ganglion neurons abolishes the anti-nociceptive effect of a selective channel opener.

Markus Valdor,Anke Wagner, Heike Fischer,Viola Röhrs,Wolfgang Schröder,Gregor Bahrenberg, André Welbers,Henry Fechner,Jens Kurreck,Thomas M Tzschentke,Thomas Christoph

Journal of Pharmacological and Toxicological Methods（2020）

引用 3|浏览7

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摘要

•AAV-mediated RNAi can generate rat models for pain research.•AAV2.7 serotype efficiently transduces neuronal cells in vivo.•AAV-mediated Kv7.2 knockdown allows demonstration of drug selectivity.

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关键词

Adeno-associated virus (AAV),Dorsal root ganglion (DRG),Kv7.2,Methods,Rat,RNA interference

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