Relevance of seminal F 2 -dihomo-IsoPs, F 2 -IsoPs and F 4 -NeuroPs in idiopathic infertility and varicocele.

•The relevance of isoprostanoids in human semen quality was investigated.•F2-dihomo-IsoPs was significantly higher in varicocele group respect to fertile men.•F2-IsoPs positively correlated with F2-dihomo-IsoPs in the whole population.•F4-NeuroPs positively correlated with sperm necrosis in idiopathic infertility group.•Isoprostanoid semen levels appear to be associated with male infertility.