Maternal high-fat diet exaggerates diet-induced insulin resistance in adult offspring by enhancing inflammasome activation through noncanonical pathway of caspase-11.

•Maternal HFD increases the vulnerability to HFD-induced IR in adult offspring.•Maternal HFD augments inflammasome activation in eWAT in adult offspring.•Treatment with an inflammasome inhibitor abrogates IR in offspring of HFD-fed dam.•Maternal HFD augments the noncanonical inflammasome activation pathway of caspase-11.•Maternal HFD augments IL-1β release from BMDMs by enhancing membrane pore formation.