Pd-Catalyzed Oxidative Annulation of Aryl Ethers with Alkynes: Synthesis of Functionalized Spirocycles and Naphthalenes.
ORGANIC LETTERS(2020)
摘要
Palladium-catalyzed dearomative [2+2+1] annulations of aryl ethers with alkynes are reported via para-selective C-H functionalization, providing highly functionalized spirocyclohexadienones in moderate to excellent yields under mild reaction conditions. Importantly, mechanistic investigation indicated an unusual C-O bond cleavage was involved. Moreover, polyarylated naphthalenes could be obtained via oxidative [2+2+2] annulation by tuning aryl ethers from monomethoxybenzenes to polymethoxybenzenes under an identical catalytic system.
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关键词
functionalized spirocycles,aryl ethers,alkynes,pd-catalyzed
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