Obesity and NRF2-mediated cytoprotection: Where is the missing link?

Liliya V. Vasileva,Martina S. Savova,Kristiana M. Amirova,Albena T. Dinkova-Kostova,Milen I. Georgiev

Pharmacological Research（2020）

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Abstract

•Evidence linking ROS overproduction to obesity-induced inflammation are present.•NRF2 activation is crucial for physiological adipocyte differentiation.•In context of obesity in humans the modulation of NRF2 needs further clarification.•NRF2 activation could be potential approach in obesity treatment.

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Key words

Acc,AhR,Akt,AMPK,ARE,ATM,BAT,BH4,BTB,BW,C/EBPs,CAT,CBP,CD,CDDO,CHD,CNCbZIP,COPD,CUL3,CYP1B1,DIO,ERK,FABP4,FAS,FFA,FGF21,GCH1,GLUT4,GPX,GSH,GSK,GST,HCD,HFD,HFFD,HO-1,IGF1,IL,IR,IVR,JNK,KD,KEAP1,KO,MAPK,MCP,MetS,mTOR,NASH,NFE2L2,nNOS,NCD,Neh,NF-κB,Nox,NQO-1,NRF2,p62,PGC1α,PPAR,RAC,RNS,ROS,RXRα,sMaf,SGBS,SOD,SQSTM1,SREBP-1,T2D,TBE-31,TG,TGF-β,TNF-α,TRAIL,WAT,WT,β-TrCP

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