De-intensification of therapy in human papillomavirus associated oropharyngeal cancer: A systematic review of prospective trials

Roshal R. Patel,Ethan B. Ludmir,Alexander Augustyn,Nicholas G. Zaorsky,Eric J. Lehrer, Rohith Ryali,Daniel M. Trifiletti,Sebastian Adeberg,Arya Amini,Vivek Verma

Oral Oncology（2020）

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摘要

•PRISMA systematic review including 10 HPV-associated de-intensification trials.•Chemoradiotherapy de-escalation strategies show promising outcomes, few toxicities.•Two trials showed superior outcomes with cisplatin versus cetuximab.•Although de-escalations strategies differ, many feasible options exist.•Long-term follow-up is required for firm treatment recommendations.

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关键词

HPV positive,De-intensification,De-escalation,Oropharyngeal,Head and neck,Radiotherapy

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