Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders

•Habituation impairments are present in multiple neurodevelopmental disorders.•Habituation and many risk genes are conserved in high-throughput model organisms.•Assessing habituation can determine the pathogenicity of risk genes and variants.•Habituation can be used to identify molecular pathways and therapeutic targets.•Entire candidate gene lists can be assessed quickly using machine vision trackers.