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Benefits and Risks of Primary Treatments for High-risk Localized and Locally Advanced Prostate Cancer: An International Multidisciplinary Systematic Review

Lisa Moris,Marcus G. Cumberbatch,Thomas Van den Broeck,Giorgio Gandaglia,Nicola Fossati,Brian Kelly,Raj Pal,Erik Briers,Philip Cornford,Maria De Santis,Stefano Fanti,Silke Gillessen,Jeremy P. Grummet,Ann M. Henry,Thomas B.L. Lam,Michael Lardas,Matthew Liew,Malcolm D. Mason,Muhammad Imran Omar,Olivier Rouvière

European Urology（2020）

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Abstract
High-risk and locally advanced prostate cancer (PCa) patients are likely to undergo multimodality treatment. Patients should at all times be fully informed about all available options and the likelihood of a multimodal approach, including the potential side effects of both local and systemic treatment.
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Key words
Prostate cancer,Localized,Locally advanced,Primary therapy,Radical prostatectomy,External beam radiotherapy,Brachytherapy,Modality treatment,Systemic treatment,Systematic review
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