PPARγ and PPARα synergize to induce robust browning of white fat in vivo.

Tobias Kroon,Matthew Harms,Stefanie Maurer,Laurianne Bonnet,Ida Alexandersson,Anna Lindblom,Andrea Ahnmark,Daniel Nilsson,Peter Gennemark,Gavin O'Mahony,Victoria Osinski,Coleen McNamara,Jeremie Boucher

Molecular Metabolism（2020）

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摘要

Dual PPARα/γ activation is superior to selective PPARγ activation at inducing browning of white fat in vivo: via PPARγ action in the adipose and a PPARα-mediated action in the liver resulting in increased circulating fibroblast growth factor 21 (FGF21).Image 1

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关键词

Brown adipocytes,Beige adipocytes,Thermogenesis,UCP1,FGF21,PPAR

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