Combined local impedance and contact force for radiofrequency ablation assessment

BACKGROUND The combination of contact force (CF) and local impedance (LI) may improve tissue characterization and lesion prediction during radiofrequency (RF) ablation. OBJECTIVE The purpose of this study was to evaluate the utility of LI combined with CF in assessing RF ablation efficacy. METHODS An LI catheter with CF sensing was evaluated in swine (n = 11) and in vitro (n = 14). The relationship between LI and CF in different tissue types was evaluated in vivo. Discrete lesions were created in vitro and in vivo at a range of forces, powers, and durations. Finally, an intercaval line was created in 3 groups at 30 W: 30s, Delta 20 Omega, and Delta 30 Omega. In the Delta 20 Omega and Delta 30 Omega groups, the user ablated until a 20 or 30 Omega LI drop. In the 30s group, the user was blinded to LI. RESULTS In vivo, distinction in LI was found between the blood pool and the myocardium (blood pool: 122 +/- 7.02 Omega; perpendicular contact: 220 +/- 29 Omega; parallel contact: 207 +/- 31 Omega). LI drop correlated with lesion depth both in vitro (R = 0.84) and in vivo (R = 0.79), informing sufficient lesion creation (LI drop >20 Omega) and warning of excessive heating (LI drop >65 Omega). When creating an intercaval line, the total RF time was significantly reduced when using LI guidance (6.4 +/- 2 minutes in Delta 20 Omega and 8.1 +/- 1 minutes in Delta 30 Omega) compared with a standard 30-second workflow (18 +/- 7 minutes). Acute conduction block was achieved in all Delta 30 Omega and 30s lines. CONCLUSION The addition of LI to CF provides feedback on both electrical and mechanical loads. This provides information on tissue type and catheter-tissue coupling; provides feedback on whether volumetric tissue heating is inadequate, sufficient, or excessive; and reduces ablation time.