Expression and role of ERAP1 in placental tissues of preeclampsia.

Objective: This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis. Methods: ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot. The location of ERAP1 was detected by immunohistochemistry. Cellular preeclampsia model was established by hypoxia treatment of HTR-8/SVneo cells (2% oxygen). Results: The present study revealed that ERAP1 expression were significantly elevated in placental tissues of preeclampsia, and hypoxiaincreased ERAP1 expression in trophoblast, suggesting that ERAP-1 may be involved in the development of preeclampsia. Conclusion: These finds highlight the role of ERAP1 in the pathogenesis of preeclampsia.