Mapping The Translational Process Of Her-2 Studies With The Pioneer'S Publications

Translational research (TR) aims to "translate" findings in fundamental research into the clinic, with the ultimate goal of better health outcomes. The term however is ambiguous and qualitative control tools have only been developed recently. They include identification and description of TR stages, as well as evolving from one stage to another. A proper evaluation of the TR in Her2 domain has not been performed thus far. Given the significance of the Her2 research and its implications into guidelines and pharmaceutical policies, we conducted a concise clustering of the pioneering publications of Dennis Slamon. Moreover we analyzed the keyword co-occurrence of the network extracted by the publications. By tracking the linkage strength within and between clusters, their dynamics and connected terms, we show how different TR stages occur and how they relate to each other. Our comprehensive mapping of the translational process of Her-2 research has implications for policy definition and implementation, as well as future TR evaluation framework