Polydeoxyribonucleotide ameliorates lipopolysaccharide-induced acute lung injury via modulation of the MAPK/NF-κB signaling pathway in rats.

•Initiation of ALI is release of inflammatory mediators.•During the onset of ALI promotes apoptosis, which increase tissue damage.•Inflammation and apoptosis by ALI is related to MAPK/NF-κB signaling pathway.•PDRN modulates MAPK/NF-κB signaling pathway to inhibit apoptosis and inflammation.•PDRN may serve as a new therapeutic option in the initial treatment of ALI.