Increased levels of IL-10 and IL-1Ra counterbalance the proinflammatory cytokine pattern in acute pediatric immune thrombocytopenia.

Nadine Goelz,Alessandra M S Bosch,Margaret L Rand,Julia J M Eekels, Francesca D Franzoso,Markus Schmugge

Cytokine（2020）

引用 13|浏览12

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摘要

•Distinct cytokines patterns in pediatric ITP compared to controls.•The pro- and anti-inflammatory activity in acute versus chronic ITP is counterbalanced.•Positive correlation of ITP platelets counts with GRO and of monocytes with IP-10.•Low PBMCs mRNA expression levels of cytokines in ITP compared to controls.

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关键词

ITP,IVIg,Cytokines,Chemokines,Autoimmune disease,Growth factors,Platelets

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