Identifying and responding to trial implementation challenges during multisite clinical trials.

Tracy L Greer,Robrina Walker,Chad D Rethorst,Thomas F Northrup,Diane Warden,Viviana E Horigian, Meredith Silverstein,Kathy Shores-Wilson,Angela L Stotts,Madhukar H Trivedi

Journal of Substance Abuse Treatment（2020）

引用 3|浏览33

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摘要

•Effective trial management requires•collaborative and ongoing problem-solving•CTN trials have expanded from specialty settings to larger general medical settings•Historical implementation lessons from earlier CTN trials can meaningfully inform future trials•We describe CTN0037's infrastructure, participant- and site- level, intervention, and longitudinal design challenges•Historical information coupled with structured monitoring can increase trial impact

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关键词

Adherence,Retention,Recruitment,Multisite trial optimization,Trial implementation,Study management

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