Visible Light-Promoted Selenylative Spirocyclization of Indolyl-ynones toward the Formation of 3-Selenospiroindolenines Anticancer Agents.
CHEMISTRY-AN ASIAN JOURNAL(2020)
Abstract
A metal-free and efficient visible-light-induced spirocyclization of indolyl-ynones with diselenides at room temperature under air atmosphere to prepare 3-selenospiroindolenines in moderate to good yields has been developed. The resulting products were tested for in vitro anticancer activity by MTT assay, and compounds 3 c and 3 e showed potent cancer cell-growth inhibition activities.
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Key words
visible-light initiation,photocatalyst-free,spirocyclization,3-selenospiroindolenines,anticancer agents
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