piRNA-unbound PIWIL1 promotes metastasis
NATURE CELL BIOLOGY（2020）
Abstract
Piwi proteins are aberrantly induced in human tumours, but their function in cancer has been poorly understood. A study now shows that in the absence of piRNA loading, human PIWIL1 promotes pancreatic cancer metastasis by acting as a co-activator of the anaphase-promoting complex/cyclosome (APC/C) to degrade the cell-adhesion protein Pinin.
MoreTranslated text
Key words
Metastasis,Piwi RNAs,Ubiquitin ligases,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined