Siphonagarofurans A-J: Poly-O-acylated β-dihydroagarofuran sesquiterpenoids from the fruits of Siphonodon celastrineus
Phytochemistry(2020)
Abstract
Ten poly-O-acylated β-dihydroagarofuran sesquiterpenoids, siphonagarofurans A-J, were obtained from the fruits of Siphonodon celastrineus using chromatographic techniques. Their structures were elucidated by extensive use of 2-D NMR spectroscopic methods. The absolute configurations of siphonagarofurans A-J were assigned following analysis of calculated and experimental ECD spectra. The absolute configuration of siphonagarofuran A was also confirmed by X-ray crystallographic analysis. Selected compounds were evaluated for their cytotoxic activity against KB, Vero and Hela cell lines with siphonagarofuran J identified as the most active compound, with IC50 values ranging from 14 to 27 μM.
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Key words
Siphonodon celastrineus,Celastraceae,β-dihydroagarofuran sesquiterpenoids,Cytotoxic activity,X-ray structure of siphonagarofuran A,ECD calculation
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