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Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate.

Søren Wedel Svenningsen,Rikki Franklin Frederiksen,Claire Counil,Mario Ficker,Jørgen J Leisner,Jørn Bolstad Christensen

MOLECULES（2020）

Cited 13|Views8
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Abstract
Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.
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Key words
antimicrobial compounds,dendrimers,Ciprofloxacin
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