Two new troponoides with anti-inflammatory activity from the stems of Juniperus formosana Hayata

Two new troponoides (1-2) were isolated from a 95% ethanol extract of the stems of Juniperus formosana (Cupressaceae), together with six known compounds (3-8). The structures of the new compounds were comprehensively characterized by high resolution electrospray ionization-mass spectrometry (HR-ESI-MS), 1D and 2D nuclear magnetic resonance (NMR). Compounds 1-7 were evaluated for their anti-inflammatory against the expression of IL-1 beta, IL-6 and TNF-alpha in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. The new compounds showed moderate anti-inflammatory effect, while other compounds did show no activity.