Immunohistochemical localization of TNF-α and IL-4 in granulomas of immunocompetent and immunosuppressed New Zealand white rabbits infected with Encephalitozoon cuniculi.
Cytokine(2020)
摘要
•TNF-a-positive cells are in brain and kidneys of immunosuppressed rabbits.•IL-4-positive cells were observed in immunocompetent and immunosuppressed rabbits.•TNF-α–positive cells were activated by Encephalitozoon cuniculi spores.•IL-4-positive cells were numerous in brain of immunocompetent rabbits.•Change of Th1- to Th2-like granulomas occurred by an unknown mechanism.
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关键词
Encephalitozoon cuniculi,Immunohistochemistry,Granuloma,Interleukin-4,Tumor necrosis factor-α,Rabbit
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