AB022. Biosynthetic implants for corneal regeneration in patients at high risk of rejecting donor transplantation

Background: Patients with inflammation or severe corneal pathology are often at high risk of rejecting the human donor corneas that they receive during transplantation. Our goal was to determine whether cell-free implants incorporating phosphorylcholine-based polymer, 2-methacryloyloxyethyl phosphorylcholine (MPC), which has inflammation suppressing properties, can support repair and regeneration of ulcerated, high-risk corneas.