A convenient synthesis of enantiopure (4aS,7aR)-1,4,4a,7a-tetrahydrocyclopenta[c]pyran-3,7-dione
Mendeleev Communications(2020)
摘要
The title compound, as the new chiral building block for bioactive cyclopentenones, was prepared in 8 steps with 15% overall yield. The key steps involve selective homologation in intermediate [(1S,2R,5R)-5-trimethysilylcyclopent-3-ene- 1,2-diyl]dimethanol by regioselective silylation followed by oxidation and the Wittig reaction.
更多查看译文
关键词
bicyclic δ-lactones,cyclopentenones,bioactive compounds,cyclopentanoids,asymmetric synthesis,lactonization,epoxidation,allylsilanes,silylation,ion-exchange resins.
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要