Muscle Complaints or Events in Patients Randomized to Simvastatin or Ezetimibe/Simvastatin

Michael G. Nanna,Ann Marie Navar,Robert P. Giugliano,Jennifer A. White,Yuliya Lokhnygina,Yale B. Mitchel,Thomas A. Musliner,Christopher P. Cannon,Michael A. Blazing

Journal of the American College of Cardiology（2020）

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摘要

Muscle-related events, including less severe muscle complaints without a clear pharmacological relationship to the treatment, may hamper compliance with lipid-lowering therapy and increase the risk of drug discontinuation ([1][1]). In IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy

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