A novel SOS1-ALK fusion variant in a patient with metastatic lung adenocarcinoma and a remarkable response to crizotinib

•SOS1-ALK fusion in lung adenocarcinoma is the first reported in the world.•NGS is important, more and more novel non-EML4-ALK fusions are identified in lung cancer by NGS.•Literature review ALK fusion partner, which have been reported before.