Where ferroptosis inhibitors and paraquat detoxification mechanisms intersect, exploring possible treatment strategies

•Paraquat (PQ) toxicity is not solely but closely related to ferroptosis.•Lipophilic antioxidants with anti-inflammatory properties mitigate PQ toxicity.•NMDAR antagonists and iron-chelators prevent iron accumulation and PQ toxicity.•ACSL4 and DPP-4 inhibitors as well as statins are promising in PQ toxicity.•COX/LOX inhibitors and VDAC modulators demand further explorations.